#!/usr/bin/perl

use strict;
use warnings;

my $file = '/path/to/file.ext';
my $tmp = $file . '.tmp';
my @unwanted = qw(ICT ProgramVariables);

open my $in, '<', $file or die $!;
open my $out, '>', $tmp or die $!;

while( my $line = <$in> ){
    next if grep{ $line =~ /^\Q$_\E/ }@unwanted;
    print $out $line;
}

close $out;
close $in;

rename $tmp, $file;